Current concepts for management of soft tissue sarcomas of the extremities.

J Surg Orthop Adv. 2008 Fall;17(3):204-15.
Papagelopoulos PJ, Mavrogenis AF, Mastorakos DP, Patapis P, Soucacos PN.

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Wide resection and limb-salvage surgery remain the gold standard for the management of patients with soft tissue sarcomas of the extremities. Innovations in understanding tumor biology and limb-salvage techniques have led amputation rates to decline. Radiation therapy and novel chemotherapy agents and dosing regimens are supplementing oncology-related surgical treatment. A multidisciplinary team approach with input from oncologists, pathologists, radiation oncologists, and orthopaedic and plastic surgeons is necessary for the management of patients with soft tissue sarcomas of the extremities.